State Route 58 is a north–south state highway in the U.S. state of Tennessee that serves as a major route for many communities in Roane County, Meigs County, and Hamilton County. Its northern terminus is at the junction of State Route 95 in Oak Ridge, and its southern terminus is at Broad Street in Chattanooga.

In Chattanooga, the portion of Route 58 is also known as Highway 58. Between State Route 153 and Riverside Drive, connecting with State Route 319, Route 58 is known as Amnicola Highway, which lends its name to the commonly known name of the main campus of Chattanooga State Community College.

Route 58 joins Interstate 40 for part of its route in Roane County, from Kingston east to the Interstate interchange west of Oak Ridge.