South Carolina Highway 265 (SC 265) is a primary state highway in the U.S. state of South Carolina. It serves to connect Jefferson with the cities of Kershaw and Chesterfield.

SC 265 is a two-lane rural highway that traverses 24.5 miles (39.4 km), from US 601, north of Kershaw, to SC 9, near Ruby.

Established in 1928 as a new primary routing from SC 26, in Kershaw, to SC 9, near Ruby. In 1940, it was extended southwest to SC 97, in Liberty Hill. In 1948, it was reduced back to its original route from 1928-1940. In 1951 or 1952, SC 265 was shortened to its current eastern terminus with US 601.