Pennsylvania Route 46 (PA 46) is a 42.4-mile (68.2 km) long state highway located in northern Pennsylvania. The southern terminus of the route is at Pennsylvania Route 120 in Emporium. The northern terminus is at the Bradford Bypass, carrying U.S. Route 219 and Pennsylvania Route 346, in Bradford roughly two miles south of the New York-Pennsylvania border.

PA 46 was first signed in 1927, extending from U.S. Route 6 in Smethport north to US 219 in Bradford. The route was extended southward to Emporium in 1928 when the eastern segment of Pennsylvania Route 47, which ran along present-day PA 46 from PA 120 in Emporium to US 6 in Smethport, was decommissioned after only one year of service.