Pennsylvania Route 392 (PA 392) is a 5.16-mile (8.30 km) long state highway located in York county in Pennsylvania. The western terminus is at PA 177 near Lewisberry. The eastern terminus is at PA 262 near Goldsboro.

PA 392 begins at an intersection with PA 177 in Newberry Township, heading east on two-lane undivided Potts Hill Road. The road winds east along a forested hill, passing a few homes. The route turns to the southeast and runs a short distance to the west of I-83. PA 392 turns north onto Old Trail Road and immediately interchanges with I-83 before heading north into a mix of woods and development. The route turns east onto Yocumtown Road and passes housing developments. Farther northeast, PA 392 runs through a mix of agriculture and homes with some woods before heading east into open farmland and ending at PA 262 in the community of Plainfield.

The entire route is in Newberry Township, York County.