Pennsylvania Route 345 (PA 345) is a state highway in the U.S. state of Pennsylvania. The route runs from Pennsylvania Route 82 in West Nantmeal Township, Chester County north to U.S. Route 422 near Birdsboro, Berks County.

PA 345 heads north from Pennsylvania Route 82 on Bulltown Road. It crosses over the Pennsylvania Turnpike (Interstate 76) and enters East Nantmeal Township, where it intersects Pennsylvania Route 401. PA 345 continues into Warwick Township, where it crosses Pennsylvania Route 23 and the name changes to Pine Swamp Road. It then enters French Creek State Park and crosses into Union Township in Berks County. PA 345 passes by the Hopewell Furnace National Historic Site and continues north and forms the eastern boundary of Birdsboro before intersecting PA 724, with which the route forms a concurrency. After PA 724 diverges, PA 345 is known as Furnace Street and Center Road as it travels north into the village of Baumstown and ends at an intersection with US 422.

In 2008, PA 345 was extended north along PA 724 and then along the former PA 82 to U.S. Route 422. At that time, PennDOT decommissioned PA 82 north of Elverson because of washed out roads between Elverson and Birdsboro.