State Route 376 (SR 376, OH 376) is a north–south state highway in the southeastern portion of the U.S. state of Ohio. State Route 376 has its southern terminus at a T-intersection with State Route 266 just across the Muskingum River from Stockport. Its northern terminus is at State Route 60 in the unincorporated community of Blue Rock.

The path of State Route 376 takes it through parts of the counties of Morgan and Muskingum. This route is not included as a part of the National Highway System.

State Route 376 made its debut in 1934. Originally, the highway ran from its current southern terminus at State Route 266 near Stockport to the former State Route 77 (now State Route 60) in McConnelsville. In 1937, State Route 637 was extended north of McConnelsville along a previously un-numbered roadway up to a new northern terminus at State Route 340 in the hamlet of Ruraldale. By 1964, State Route 340 was truncated to its current western terminus at State Route 284. The portion east of State Route 376 would become knownas county-maintained Ruraldale Road, while the portion to the west would become an extension of State Route 376 that would take it to its current northern terminus at State Route 60 in Blue Rock.