County Route 533, abbreviated CR 533, is a county highway in the U.S. state of New Jersey. The highway extends 32.36 miles (52.08 km) from the White Horse Circle, in Hamilton Township to County Route 527 in Bound Brook. Route 533 shares a major concurrency with U.S. Route 206 through Princeton, while portions of the roadway in Somerset County are part of the Millstone River Valley Scenic Byway.

Along with Route 206, CR 533 is one of the main roads connecting Mercer and Somerset, as evidenced by the fact the two cross the county line together.

It also has a key historic importance, as George Washington used the road during his march from Trenton to Princeton during the American Revolution. This is commemorated by several small stone pillars at various points along the road.

The southern third of CR 533 serves as a shorter, more direct route between two parts of Route 206, connecting the southern portion as it travels north from Bordentown and the northern portion as moves through Princeton and into Somerset County. The U.S. highway turns west down Broad Street at the circle and winds confusingly through the city of Trenton before moving through Lawrence, the county route continues nearly due north through Hamilton and along the Lawrence/West Windsor boundary into Princeton. (Route 524 also begins at the circle, following Broad in the other direction toward Yardville and Allentown.)

For its first 3.5 miles (5.6 km) in southern Hamilton, the route is White Horse-Mercerville Road, as it connects the two census-designated places. Along the way, it accesses both interstates 295 (Exit 61) and 195 (Exit 2) via Arena Drive, just 0.42 miles (0.68 km) from the southern terminus. At 3.3 miles (5.3 km), it intersects Route 33, providing access to downtown Trenton and the business-laden stretch of Hamilton Square. Less than a mile later, CR 533 meets Route 535 and Nottingham Avenue at a five-point intersection, and continues on as Quakerbridge Road.

At this point, the route picks up the trail followed by Washington. At 4.39 miles (7.07 km), it passes Sloan Avenue, which again provides access to I-295 at Exit 65. From here, it continues on to the northern border of Hamilton and follows the border between Lawrence to the west and West Windsor on the east. It crosses Amtrak's Northeast Corridor at 6.70, just north of the Hamilton Transit Complex. It passes the Quaker Bridge Mall complex to the left as it approaches U.S. Route 1, which it crosses at 8.05.

Officially, Quakerbridge becomes Quaker Road, but it is signed as Quakerbridge at the upcoming intersection with Province Line Road, which runs along the old Province Line between East Jersey (Princeton) and West Jersey (Lawrence). Upon crossing that line, CR 533 moves into a heavily wooded area, crossing the Delaware & Raritan Canal at Port Mercer, then the Stony Brook over the Quaker Bridge, winding its way toward Route 583, which is the old turnpike from Trenton to Princeton. It crosses 583 and continues to the start of its concurrency with Route 206.

During its six and a half-mile concurrency with Route 206, CR 533 services Nassau Street (Route 27) in downtown Princeton and Princeton Airport near an intersection with Route 518 in Montgomery Township, just beyond the county line between Mercer and Somerset. Just before the end of the concurrency, the road passes over Bedens Brook.

CR 533 finally splits off of Route 206 in northern Montgomery at mile marker 17.33, breaking off to the right and running along the western bank of the Millstone River, which is itself parallel to the Delaware & Raritan Canal for this stretch. It is now known as River Road, and there is a Canal Road that also mirrors CR 533 on the far side of the two waterways in Franklin Township.

At 21.59, CR 533 meets Township Line Road from the left, marking the move from Montgomery into Hillsborough. At 24.88, it enters the borough of Millstone for about a mile. Here, it interchanges Amwell Road (Route 514), which provides access to a spur of CR 533. Just before mile marker 26, the route re-enters Hillsborough and meets up with the northern end of the spur.

At 27.19, CR 533 passes by the Central Jersey Regional Airport, then turns away from the river as it becomes Main Street in the densely packed borough of Manville. After two miles (3 km), CR 533 crosses the Raritan River over Van Veghten's Bridge and enters Bridgewater. At 29.89, CR 533 reaches the downtown Bridgewater, and turns right down its Main Street, traveling almost due east for its remaining two and a half miles. In its busy final mile, it passes by TD Bank Ballpark, the Bridgewater Train Station and Interstate 287, enters Bound Brook and reaches its terminus at Route 527. There is no direct access to I-287, but Promenade Boulevard does carry traffic to Route 28 at Exit 13 off the freeway.

Despite the ending of the CR 533 designation, the road itself continues as CR 607. It passes through a traffic circle, where CR 527 leaves to the south toward South Bound Brook, and crosses county lines into the borough of Middlesex, where it ends at an intersection with Route 28.

County Route 533 Spur (formerly known as County Route 533 Bypass) is a county highway in the U.S. state of New Jersey. The highway extends 0.45 miles (0.72 km) from Millstone Bypass (CR 514) in Millstone to Millstone River Road (CR 533) in Hillsborough Township.

The road travels through the following municipalities at the specified mileposts (from South to North):