Mississippi Highway 53 (MS 53) is a state highway in Mississippi. The highway runs approximately 40 miles (64 km) from Lyman to Poplarville and is part of the Mississippi Highway System. It serves a total of 3 counties (Pearl River, Hancock and Harrison). The highway begins at the intersection of U.S. Highway 49 in Lyman and ends at the intersection of Mississippi Highway 26 in Poplarville.

From South to North