Route 180 is a highway in the St. Louis, Missouri area. Its eastern terminus is at Goodfellow Boulevard in St. Louis where the road is known as Martin Luther King Drive; its western terminus is just west of Interstate 270 in Bridgeton at the Missouri River.

The road is locally named St. Charles Rock Road in most of St. Louis County and Martin Luther King Drive in the City of St. Louis and in Wellston.

A spur of Highway 180 goes south into Pagedale to connect also with Route D (Page Avenue) and is known as Pennsylvania Avenue.