State Route 222 is a route from Corinna at State Routes 7, 11, and 43 to US Routes 2 and 2A in Bangor. The route is 27.42 (44.13 km) long.

Route 222 begins at an intersection with concurrent US Routes 2 and 2A. The route heads northwest to cross Interstate 95. After it crosses Interstate 95, the route is next to the Bangor International Airport. In the town of Levant, the route turns left but is not concurrent. In the town of Stetson it crosses State Route 143. Then, the route makes it to its northern end in Corinna.