Maryland Route 286 (MD 286) is a state highway in the U.S. state of Maryland. Known for most of its length as Bethel Road, the state highway runs 2.09 miles (3.36 km) from George Street, which is one of the segments of unsigned MD 537, east within Chesapeake City to the Delaware state line, where the highway continues east as Delaware Route 286 (DE 286). MD 286 roughly parallels the south side of the Chesapeake and Delaware Canal in southern Cecil County. MD 286 was constructed around 1930. The state highway originally served the lost community of Bethel near the state line, but was rerouted to the Delaware state line in the early 1960s due to expansion of the canal.

MD 286 begins at an intersection with George Street (unsigned MD 537C) on the south side of Chesapeake City. The state highway heads east as two-lane 2nd Street through the South Chesapeake City Historic District. At Bohemia Avenue, MD 286 becomes Bethel Road and curves around the Back Creek Mooring Basin. After crossing Back Creek, the state highway makes a right-angle turn at the entrance to the Chesapeake and Delaware Canal Museum. MD 286 leaves the town limits of Chesapeake City and passes through a forested area along the south boundary of the Canal Wildlife Management Area. Shortly after the intersection with Bethel Cemetery Road, the old alignment of MD 286, the state highway reaches its eastern terminus at the Delaware state line. The highway continues east as DE 286 (Bethel Church Road).

MD 286 originally connected Chesapeake City with Bethel, a small community on the south side of the Chesapeake and Delaware Canal just west of the state line. The state highway was paved from George Street, which is the original alignment of U.S. Route 213 (now MD 213), east along Bethel Road and then north along what is now Bethel Cemetery Road in 1930. MD 286 was disconnected from US 213 when the Chesapeake City Bridge was completed in 1948 and George Street was designated MD 537C. Bethel was evacuated shortly before the Chesapeake and Delaware Canal was expanded in the 1960s. As a result, MD 286 was removed from Bethel Cemetery Road and extended east to the state line in 1961. On the other side of the border, Bethel Church Road from the state line east to DE 15 was designated DE 286 around 1994.

The entire route is in Cecil County.