Maryland Route 216 is a Maryland route, or state highway, that runs between Laurel and Highland, primarily within Howard County. The local road name for Route 216 is Scaggsville Road.

MD 216 begins at the intersection between 7th St and Gorman Avenue (eastbound MD 198) in downtown Laurel. After crossing Talbot Ave (westbound MD 198) the route continues northward as an inner-city street, eventually crossing Montgomery St and Main St. At the Main St intersection, maintenance responsibility for MD 216 switches from the city of Laurel to MDOT SHA. Beyond Main St., MD 216 assumes the name of Scaggsville Rd. (though most signage in Prince George's County uses the "MD 216" notation) and continues north, crossing the Patuxent River via a high-level bridge about a mile downstream from Rocky Gorge Reservoir. Continuing to the northwest, the route intersects All Saints Rd. at a traditional traffic light and Stephens Rd. via ramp before upgrading to a limited-access expressway. In this format, the route interchanges with Interstate 95 at a full cloverleaf. Northwest of the interchange, MD 216 crosses Leishear Road near a major BG&E electrical substation, continuing northwest before meeting US 29 at a folded-diamond interchange in Scaggsville controlled by two traffic circles. After crossing US 29, MD 216 downgrades to a two-lane country road and continues to the north-northwest, passing through Fulton before reaching its northern terminus at MD 108 in Highland.

The realignment of MD 216 between I-95 and US 29 was completed to address expected growth and increased traffic demands. Prior to this realignment, MD 216 was a broken route; the limited-access expressway ended at Leishear Rd., and traffic was forced to turn left and access MD 216's original alignment via the county-maintained street. With the completion of the limited-access parkway between Leishear Rd. and US 29, MD 216 is now a continuous route between MD 108 in Highland and MD 198 in Laurel; Old Scaggsville Rd. (MD 216E and MD 983) survives under state maintenance.

Funding for the construction of the missing segment of MD 216 was provided by the developer of property in the northeast and northwest quadrants of the I-95/MD216 interchange.

Prior to the 1950s, MD 216 extended eastward from Laurel into Anne Arundel County with an eastern terminus at Fort Meade, near the current eastern terminus of MD 198. Instead of entering Laurel at 7th Street, MD 216 crossed the Patuxent River over a now-defunct bridge at 9th Street.

MD 216 turned east onto Main Street and followed it past the one-lane railroad bridge to Main Street's current eastern end. At that point, MD 216 turned northeast and crossed another now-defunct bridge over the Patuxent River onto the grounds of Laurel Park in Anne Arundel County.

For some time after this path changed in the 1950s, MD 216 continued south on 9th Street to a terminus at MD 198.

Prior to the 1950s, MD 216 extended across the Laurel Park grounds toward the current intersection of MD 198 and Brock Bridge Road. The portion of MD 216 between Laurel and Fort Meade was known as Old Camp Meade Road. When the route was disjointed by the construction of the Baltimore-Washington Parkway in the early 1950s, the "MD 216" designation was removed within Anne Arundel County. Three state-maintained segments of this road remain:

The rest of this former eastward section of MD 216 was subsumed by MD 198 (Laurel Fort Meade Rd), business and residential development, and nature.