Kentucky Route 16 (KY 16) is a state highway in the U.S. state of Kentucky. It follows a southwest-northeast course, paralleling Interstate 71 from U.S. Highway 127 at Glencoe northeast to Walton and continuing northeast and north into Covington, where it ends at KY 17.

Gallatin County U.S. Highway 127 to Walter Road 10 Miles West of Crittenden it is known simply at Kentucky 16 or just 16