Iowa Highway 152 (Iowa 152) is a very short route which connects Interstate 35 (I-35) and U.S. Route 69 (US 69) near Osceola, Iowa. Through Iowa, I-35 and US 69 are mostly parallel routes; Iowa 152 connects the two routes at the narrowest location between them. The route was formed in 1980 from a portion of Clarke County Road R35 and has not undergone any changes in alignment since its designation.

Iowa 152 begins at a diamond interchange along I-35 northwest of Osceola. CR R35 continues along the roadway to the north and west as Iowa 152 heads to the south-southeast. It passes country homes and wooded acreages along a two-lane road. Two-thirds mile (1.1 km) east of I-35, the highway curves to the south as it passes between farms. Just one-fifth mile (0.32 km) from its eastern end, it curves back to the east and crosses the city limits into Osceola. Iowa 152 ends at an intersection with US 69, which runs along Main Street in Osceola. The rural portion of the highway has an annual average daily traffic of 940 vehicles, while the portion within the city limits handles 1270 vehicles.

Iowa Highway 152 was designated in 1980 from a segment of CR R35. It was entirely paved upon designation and has not undergone any route changes.

The entire route is in Clarke County.