State Route 105 (SR 105) is a state highway in the northeast part of the U.S. state of Georgia. The highway runs 23.1 miles (37.2 km) from a point northwest of Clarkesville southeast through rural portions of Habersham and Banks counties to a point in rural northeastern Banks County. Approximately 1.2 miles (1.9 km) before it reaches its eastern terminus, it runs along the Banks-Stephens county line. Its eastern terminus is at the meeting point of Banks, Stephens, and Franklin counties.

SR 105 begins at an intersection with SR 17 northwest of Clarkesville. It heads south, southwest, and southeast to an intersection with SR 115. The route heads southeast, and crosses the Soquee River before intersecting US 441 BUS/SR 385 south of Demorest. The two routes begin a concurrency to the southeast. Just after the beginning of the concurrency is an intersection with US 23/US 441/SR 15 in Cornelia. After this intersection, the concurrency with US 441 BUS continues. Farther south in the city is two intersections with Georgia State Route 946. In Baldwin, the concurrency intersects US 441/SR 15, at which point, US 441 BUS ends. SR 105 begins a concurrency with the two routes.

Southeast of Baldwin, SR 105 departs to the east. The rest of the route heads through the Chattahoochee National Forest. It meets its eastern terminus at the meeting point of Banks, Stephens, and Franklin counties.