State Route 215, also known as SR-215, is a numbered state highway in Tuscaloosa County, Alabama. SR-215 partially follows the former routes of U.S. Highway 82 and U.S. Highway 11. The route stays almost completely within the city limits of Tuscaloosa.

The 8-mile (13 km) highway is unusual in that it follows both a north–south and east–west routing (though it is signed as north–south for its entire route). The highway follows the former routings of U.S. Highway 82 and U.S. Highway 11 and thus doesn't act as a true bypass for either. Even more strangely, the north–south section parallels US-82, an even-numbered (and therefore east–west) US highway, while the east–west section follows US-11, which is odd-numbered and thus follows a north–south route.

The north–south section is named Old Montgomery Highway and Greensboro Avenue while the east–west section is named University Boulevard. The route changes direction at the intersection of Greensboro Avenue and University Boulevard in downtown Tuscaloosa.

The entire route is in Tuscaloosa County.