State Route 15 is a west–east route from Memphis, Tennessee to Monteagle. For much of its route it is concurrent with U.S. Route 64.

SR-15 begins at an intersection with SR-14, the Austin Peay Highway, in northern Memphis. It proceeds east through Shelby County and intersects US-70, where it begins a concurrency with US-64. The cosigned routes cross I-40 and SR-385 (future I-269). SR-15 and US-64 travel together through Fayette, Hardeman, McNairy, Hardin, Wayne, Lawrence, Giles, Lincoln, and Franklin Counties.