North Carolina Highway 51 is a primary state highway in the state of North Carolina. Primarily in the Mecklenburg County, it runs from the South Carolina state line, in Pineville, to Mint Hill.

Though NC 51 begins at the state line, SC 51 is a short 1-mile (1.6 km) road that connects with US 21 near Fort Mill. Crossing the state line, NC 51 quickly becomes a 4-lane road as it goes through the town of Pineville. After its first intersection with Interstate 485, it enters the Charlotte city limits. In Charlotte, NC 51 crosses the busy intersections of Johnston Road and Providence Road, known for rush-hour traffic during the weekdays. In Matthews, NC 51 bypasses the main downtown area, followed by a semi-controlled interchanged with US 74 (Independence Boulevard). As the NC 51 enters Mint Hill, the road narrows to 2-lane. NC 51 crosses intersects with Interstate 485 again, before ending at NC 24/NC 27 (Albemarle Road).

The entire route is in Mecklenburg County.

Though the highway is commonly known as "NC 51" throughout the state, the highway does have other known names it uses locally in areas.