State Route 75 is a state highway in Alabama that extends 130 miles (210 km) northeastward from Birmingham to the Georgia state line. The route runs west of U.S. Highway 11 and roughly parallels that route as well as Interstate 59. Other Cities and towns along the route include Center Point, Pinson, Oneonta, Albertville, Fyffe, and Rainsville.

The southern terminus of SR-75 is at the junction with Interstate 59 and U.S. Highway 11 at the intersection of Parkway East, Roebuck Drive and Gadsden Road in eastern Birmingham. Until the 1990s, SR-75 overlapped US-11 along 1st Avenue North into downtown Birmingham, continuing to the junction of the two routes with U.S. Highway 78.

After leaving Birmingham and Jefferson County, the route of SR-75 takes it through rural areas of Blount County, Marshall County and DeKalb County. In 1999, work was completed widening SR-75 to four lanes into Oneonta. North of Rainsville, SR-75 leads toward Trenton, Georgia. North of the Georgia state line, the route is numbered State Route 301.