Texas State Highway 220 (SH 220) is a Texas state highway located in Hamilton and Erath Counties.

SH 220 begins at an intersection with SH 6 in Hico. The route travels generally to the northeast, and the only highway intersection between its termini is with FM 2481, approximately four miles north of Hico. SH 220 ends at an intersection with US 67 west of Chalk Mountain.

SH 220 was designated between 1936 and 1939 along its current route. The route retained its designation during the reorganization of the state highway system in 1939.