South Carolina Highway 5 (abbreviated SC 5) is a state highway in the U.S. state of South Carolina. It runs from US 521, near Van Wyck, to Interstate 85/SC 198, in Blacksburg.

SC 5's eastern terminus is at a rare country interchange at US 521. This is one mile (1.6 km) south of Andrew Jackson State Park and approximately nine miles north of Lancaster and at the bridge of I-85 exit 102 SC 5 ends into SC 198.

SC 5 begins as a rural road and runs at 55 mph (89 km/h) for most of the run before entering Rock Hill. SC 5 intersects Old Hickory RD nearly one and a quarter miles into its existence. Old Hickory is the main road to Van Wyck. A mile and a half further up the road, SC 5 serves as the western terminus for S.C. Highway 75. After crossing the CSX line, SC 5 rides for nearly seven miles before entering Rock Hill, South Carolina. There, it merges with US 21 northbound and becomes known as South Anderson Road.

US 21 and SC 5 overlap for about four miles (6 km) before US 21 merges off right after crossing I-77. However, immediately SC 5 becomes concurrent with S.C. Highway 72. They quickly head off again, and SC 5 heads straight towards downtown Rock Hill, where it splits off and becomes two one-way roads for about a mile, and also where it crosses US 21 Business and S.C. Highway 122.

One mile out of downtown Rock Hill, SC 5 crosses over S.C. Highway 322. From there, after a couple of suburban miles, SC 5 enters downtown York. One mile before entering, SC 5 splits off a business route (described in detail later).

Also, at that intersection, SC 5 becomes concurrent with S.C. Highway 161, where the combined highway crosses over S.C. Highway 49 nearly a mile and a half later.

After rim-riding the north side of York, SC 161 and SC 5 split their different ways. After leaving York, SC 5 is known as Black Highway. Eight miles after leaving York, SC 5 serves as the western terminus for S.C. Highway 55. Also, after running into SC 55, SC 5 serves as the northern terminus for S.C. Highway 97.

Another seven-mile (11 km) or so stretch, SC 5 enters Blacksburg, SC 5 ends at the south end of the bridge that crosses I-85 at exit 102.

Currently, there is one business loop along SC 5:

SC 5 Business follows the old route of SC 5 through downtown York, via Liberty Street. The highway begins on SC 5 just a mile and a half away northwest from downtown York. Connects with US 321/SC 161 and US 321 Business. After passing through the downtown area it links to the northern terminus of SC 324 before eventually rejoining mainline SC 5 southeast of York.