North Carolina Highway 144 is a primary state highway in the U.S. state of North Carolina. It runs from Laurel Hill to Wagram, in the North Carolina Sandhills.

A two-lane rural highway, it traverses 12 miles (19 km), from Laurel Hill to Wagram. NC 144 provides an alternate route for US 74 traffic to reach US 401, while avoiding Laurinburg.

Established in February, 2002 as a new primary route connecting Laurel Hill and Wagram, unchanged since. This is the second incarnation of NC 144.

The first NC 144 was established in 1921 as an original state highway, running from NC 14 (now NC 86), in Prospect Hill, to NC 13, in Roxboro. In 1925, it was extended west as new routing to NC 62. In 1932, NC 144 was extended northeast as new routing, ending at NC 562 (now NC 96), in Virgilina. In 1936, was extended southwest as new routing to NC 61. In 1940, NC 144 was renumbered as NC 62, from NC 61 to Pleasant Grove, and NC 49, from Pleasant Grove to Virgilina.

The entire route is in Scotland County.