State Route 16 (SR 16) is a state highway that runs west-to-east through portions of Haralson, Carroll, Coweta, Spalding, Butts, Jasper, Putnam, Hancock, and Warren counties in western and central Georgia. The route runs from its western terminus at SR 100 northwest of Mount Zion to its eastern terminus at US 278 and SR 12 in Warrenton.

The route starts just south of I-20 in southwestern Haralson County, and runs southeast into Carroll County and Carrollton, where it begins a concurrence with US 27. SR 16 continues through Whitesburg and crosses into Coweta County and through Newnan, where its overlap with US 27 ends, crossing I-85 just east of Newnan.

Turning sharply east, the route runs through Sharpsburg, turns slightly southeast, and travels through Senoia into Spalding County, turning back east, and running into Griffin. Turning slightly northeast, SR 16 crosses I-75 at the county line with Butts County and runs into and through Jackson on into Monticello in Jasper County.

Continuing east, the route crosses into Putnam County, through Eatonton, then turns southeast at the county line with Hancock County, heading on into Sparta. Turning first slightly northeast, then southeast, SR 16 continues into Warren County, where it turns northeast once more and on to its eastern terminus in Warrenton.