State Route 141 (Peachtree Road, Peachtree Boulevard, Peachtree Industrial Boulevard, Peachtree Parkway, and Medlock Bridge Road) is a south-to-north state route, which begins where Roswell Road (US 19/SR 9) and Peachtree Road split in Buckhead. It continues northward through Brookhaven, Chamblee, Doraville, Dunwoody, Peachtree Corners, Berkeley Lake, and Johns Creek to Cumming, where it comes to an end just after its intersection with Georgia 400 at exit 13. For about four miles (6 km) north of Interstate 285, SR 141 is a freeway. At the end of the freeway, SR 141 splits from Peachtree Industrial Boulevard and follows Peachtree Parkway. Peachtree Industrial Boulevard continues north past Duluth.

In Buckhead, SR 141 has a spur route: SR 141 Connector (Lenox Road). This state highway connects Peachtree Road (SR 141) and Piedmont Road (SR 237), and is very heavily traveled.

Interchanges on State Route 141 are not numbered.