State Route 68 is a 53-mile (85 km) long route in the northeastern part of the state. The western terminus of the route is at its junction with State Route 75 slightly northeast of Albertville. The route continues until it reaches the Alabama-Georgia state line becoming State Route Georgia State Route 114 once it enters the Peach State.

State Route 68 begins at the foothills of the Appalachian Mountains northeast of Albertville. There are numerous curves along the route as it passes through DeKalb County. The route maintains a generally eastward trajectory between Albertville and Collinsville. East of its junction with U.S. Highway 11, the route turns southeastwardly, continuing this orientation until it approaches Leesburg.

At Leesburg, State Route 68 and U.S. Highway 411 junction and begin a five-mile (8 km) concurrency as they cross Weiss Lake and Dam and approach Centre. State Route 68 diverts from US-411 and creates a concurrency with State Route 9 as the two routes again cross the lake, diverting from each other at Cedar Bluff. From there, State Route 68 travels northeastwardly as it approaches the Alabama-Georgia state line.