Interstate 759 (I-759) is a part of the Interstate Highway System in the US state of Alabama. It is a spur route that runs for 4.54 miles (7.31 km) between the cities of Attalla and Gadsden in Etowah County. It begins at an Interstate 59 (I-59) in Attalla and ends at U.S. Highway 411 (US 411) in southern Gadsden adjacent to the Gadsden Mall. The route continues east as the at-grade thoroughfare State Route 759 (SR 759) until the route ends at State Route 291 in Gadsden.

I-759 begins at Exit 182 of I-59 in Attalla. From this point the route travels in an easterly direction across a marshy area prior to reaching its first exit at Black Creek Parkway, a diamond interchange. From the Black Creek exit, I-759 continues in its easterly direction and crosses Neely Henry Lake along a causeway and short bridge prior to reaching US 411. At the US 411 interchange, the I-759 designation ends, but the route continues as SR 759 in spanning the Coosa River.

A new four lane bridge crossing the Coosa River opened in 2004.

Currently, there are plans to extend I-759 east to U.S. Highway 278 on the east side of Gadsden, as well as west towards Attalla and linking it to State Route 77.

The Christian Owens Project (not yet sent) plans to extend I-759 from Gadsden to merge with U.S. Highway 278 when leaving Piedmont, Alabama, and extending all the way as I-759/US 278/SR 74 in Alabama. In Georgia (I-759/US 278/SR 6) and ending 12 Miles west of Atlanta near Exit 44 on I-20 in Georgia. These plans are not currently sent so it is not in action as of 2012.

The entire route is in Etowah County.