State Route 552 (SR 552) is an east-west state highway in southern Ohio. The western terminus of State Route 552 is at State Route 220 about 2.5 miles (4.0 km) miles west of Waverly. Its eastern terminus is at State Route 104 nearly 2 miles (3.2 km) southwest of Waverly.

State Route 552 is located entirely within Pee Pee Township in northern Pike County. The highway follows the north shore of Lake White, while the corresponding state route following the south shore of the lake is State Route 551.

Starting from a T-intersection with State Route 220 southwest of Waverly, State Route 552 travels in an east-southeasterly direction, before turning more to the south-southeast, bounded by woods on the north side and the north shore of Lake White on the south side. Cottages line both sides of the state highway for most of its length. and side streets on both the north and south sides link State Route 552 with addition lakeside or woods-bounded dwellings. The route trends more to the southeast, then curves to the east-southeast, finally bending to the northeast as it enters into its terminal intersection at State Route 104 at a sharp angle. Because of this, a short connector road is provided to facilitate movements between Eastbound State Route 552 and Southbound State Route 104, as well as between Northbound State Route 104 and Westbound State Route 552.

State Route 552 is not included as a part of the National Highway System, a network of highways deemed vital for the country's economy, defense and mobility.

State Route 552 made its debut in 1937, along the route that it occupies today along the northern edge of Lake White. No significant changes have taken place to the routing of this state highway since its certification.

The entire route is in Pee Pee Township, Pike County.