State Route 112 is a Georgia state highway that runs in a generally south-to-north orientation from Cairo in Grady County to Milledgeville in Baldwin County.

SR 112 runs north from its southern terminus in Cairo in Grady County to Camilla in Mitchell County, then angles northeast and runs to Sylvester in Worth County. From there it continues northeast to Ashburn in Turner County, crosses I-75, and runs through Rebecca to Rochelle in Wilcox County. The route now turns north and runs to Hawkinsville in Pulaski County, before angling northeast yet again and running through Cochran in Bleckley County to Allentown in Wilkinson County, crossing I-16. Soon after crossing US 441/SR 29, the route turns north once again and runs into Milledgeville, its northern terminus.