M-106 is the designation given to a state trunkline highway in the Lower Peninsula of the US state of Michigan near the city of Jackson. M-106 travels in a southwest-to-northeast direction from Jackson to Gregory at a junction with M-36 just a few miles northwest of Hell. In Jackson, M-106 travels next to the G. Robert Cotton Correctional Facility, one of the world's largest maximum security prisons.

M-106 starts in downtown Jackson at the corner of Cooper Street and Michigan Avenue. Michigan Avenue runs east–west carrying Business Loop Interstate 94 (BL I-94), Business US 127 (BUS US 127) and M-50. Cooper Street runs north from here carrying M-106 through an interchange with I-94 and US 127 and north out of town. The highway curves northwest following Bunkerhill Road before turning onto Plum Orchard Road and running east into the community of Munith. M-106 merges onto Territorial Road east of the town before crossing the county line into Ingham County. South of Stockbridge, M-106 merges with M-52 and the two run concurrently into that community. M-106 turns east in the downtown and continues along Morton Road into Livingston County. The highway ends at a junction with M-36 in Gregory.

M-106 is maintained by MDOT like other state highways in Michigan. As a part of these maintenance responsibilities, the department tracks the volume of traffic that uses the roadways under its jurisdiction. These volumes are expressed using a metric called annual average daily traffic, which is a statistical calculation of the average daily number of vehicles on a segment of roadway. MDOT's surveys in 2010 showed that the highest traffic levels along M-106 were the 15,474 vehicles daily south of I-94; the lowest counts were the 1,550 vehicles per day in near the M-36 junction. The only section of M-105 has been listed on the National Highway System (NHS) is between M-50 and I-94 in Jackson. The NHS is a network of roads important to the country's economy, defense, and mobility.

M-106 was first designated in 1928 on a route that ran from US 12 (Michigan Avenue) along Cooper Street to Bunkerhill Road, a total of 4 + 1⁄2 miles (7.2 km). This highway was extended north to Stockbridge in late 1930 or early 1931. A further realignment of M-36 resulted in the extension of M-106 to Gregory. Cooper Street in Jackson was converted to one-way, southbound traffic in 1967. A northbound routing along Milwaukee Street was established. The south end of southbound M-106 was trimmed back to end at BL I-94/BUS US 127/M-50. Two-way traffic was restored in 2004. M-106 was shifted to run only along Cooper Street (formerly Milwaukee Street), and Francis Street (formerly Cooper Street) is left as an unsigned trunkline.