Illinois Route 57 is a north–south state highway in western Illinois. It runs from Interstate 172 in Fall Creek to U.S. Route 24 and Illinois Route 104 in Quincy, a distance of 12.59 miles (20.26 km).

Illinois 57 runs from Fall Creek northwest to Quincy. It is known as the Gardner Expressway in and near Quincy.

SBI Route 57 was the current U.S. Route 41 from Highland Park to Chicago. In 1949 it was moved to Hull to Quincy. In 1999 it was shortened to its current length after Interstate 172 was completed.

The entire route is in Adams County.