Pennsylvania Route 449 (PA 449) is an 17-mile (27 km) long state highway located in Potter county in Pennsylvania. The southern terminus is at US 6 in Walton. The northern terminus is the New York state line in Genesee Township.

PA 449 begins at an intersection with US 6 in the community of Walton in Ulysses Township, heading northwest on Brookland Road. The road heads through forested mountains in the Susquehannock State Forest before coming to the community of Brookland. After passing through more forests, the route enters agricultural areas and becomes Gold Road, intersecting PA 49 in the community of Gold. From this point, PA 449 turns north and continues through a mix of farmland and woodland in a narrow valley. The road briefly enters Allegany Township before heading into Genesee Township and passing through the community of Harmontown. The route runs through more rural areas before intersecting PA 244 in the community of Genesee. Here, PA 244 turns north to form a concurrency with PA 449 on Main Street, with the road passing homes and businesses. PA 449 splits from PA 244 by heading northwest on North Genesee Street into a mix of farms, woods, and homes. PA 449 ends at the New York border, where the road becomes NY 19.

The entire route is in Potter County.