Route 150 is a short south–north highway entirely in Amesbury, Massachusetts.

Route 150 begins at an intersection with Beacon Street, an unusual instance that a numbered route does not have its terminus with another numbered route. About a half mile north is the intersection with Interstate 495, and the intersection with Route 110 is about one mile (1.6 km) further north. Route 150 then becomes the primary thoroughfare through the center of the city. The highway becomes New Hampshire Route 150 upon crossing the state line.