US 221 (SC) Intersections with interstate highways 2025-10-29 Roadnow US 221 (SC) Intersections with interstate highways MAP I-85, near Spartanburg, Maryland map • nearbyMAP I-26, near Roebuck, Maryland map • nearbyMAP I-385SC, near Laurens, Maryland map • nearbyMAP I-26, near Roebuck, Maryland map • nearbyMAP I-585SC, near Spartanburg, Maryland map • nearbyMAP I-585SC map • nearbyMAP I-585SC, near Spartanburg, Maryland map • nearby
