West Virginia Route 10 is a north–south route from Cabell County to Mercer County in the western and southern regions of West Virginia. The road is of very poor quality for most of its path, following river vallies and carved into the side of mountains.

Between the towns of West Hamlin and Man, most of the route closely parallels the course of the Guyandotte River. Thus, it follows a very winding course, with a solid rocks just inches from the roadway, and is thus very dangerous. It is currently receiving an upgrade from Man to Logan to a four lane highway built to the same standards as the Appalachian Corridor system. Currently about one-third of the route is finished and open to traffic, between Man and Rita. The section from Rita to Logan is under construction.

Further north in Cabell County, the segment from Interstate 64 in Huntington, where the current four-lane portion ends, to eight miles (13 km) south is also slated for four-lane widening. The existing facility is two lanes with numerous curves. In 2005, 14 houses were demolished in preparation for the highway's realignment, however construction has been left "unfunded" and has not begun.

In Huntington, portions of the highway are named Troy Brown Way and Hal Greer Boulevard in honor of two notable local professional athletes.

West Virginia Route 10 Alternate is a four-mile-long north–south road near Barboursville, West Virginia connecting WV 10 to the south and US 60 to the north. It acts as an alternative route to Huntington and eliminates many of the curves that plague WV 10 south of Interstate 64 to the WV 10 Alternate junction.