Pennsylvania Route 382 (PA 382) is an 12-mile (19 km) long state highway located in York County in Pennsylvania. The western terminus is at PA 114 near Bunches. The eastern terminus is at PA 181 in York Haven.

PA 382 begins at an intersection with PA 114 in Fairview Township, heading south on two-lane undivided Lewisberry Road. The road heads through forested areas before passing through the community of Nauvoo and passing a mix of farms, woods, and homes. The route turns southeast and runs through more farmland and woodland. PA 382 passes rural areas of residences as it becomes the border between Lewisberry to the northeast and Newberry Township to the southwest, intersecting PA 177. The route curves east and fully enters Newberry Township, passing through agricultural areas. Farther east, the road runs through wooded areas with a few homes before reaching an interchange with I-83.

After this, PA 382 passes through the community of Newberrytown and continues past rural areas of residences as York Haven Road. The road passes through a patch of farmland before entering forested areas with some homes and turning southeast. The route crosses PA 295 in the community of Pleasant Grove before intersecting PA 262 a short distance later. PA 382 continues into York Haven and becomes Landvale Street, making a curve northeast to enter residential areas. The route turns east onto Pennsylvania Avenue and continues to its eastern terminus at an intersection with the northern terminus of PA 181.

The entire route is in York County.