Highway 549 is the temporary designation of Future Interstate 49 southeast of Texarkana. Designated a distance of 29.49 miles (47.46 km), Highway 549 first opened to traffic in December 2004 between Texarkana and Fouke. A second section, between Fouke, and Doddridge, opened October 21, 2005.

Its northern terminus is at Highway 245 along the Loop, roughly 1.5 miles (2.4 km) east of South State Line Avenue and the border with Texas. Its southern terminus is currently at U.S. Highway 71 4.32 miles (6.95 km) north of the Louisiana state line. Construction on this segment to the state line began in 2010 to complete the road between US 71 and the state line.

The entire route is in Miller County.