Route 160 is a state highway in Connecticut running for 7.36 miles (11.84 km) from the Berlin Turnpike (US 5 and Route 15) in Berlin to Route 17 in the South Glastonbury section of Glastonbury. The road crosses the Connecticut River on the Rocky Hill - Glastonbury Ferry. It passes over I-91 in Rocky Hill with no interchange.

Route 160 begins at an intersection with US 5 and Route 15 in northeastern Berlin and heads east into Rocky Hill. In Rocky Hill, it continues east to a brief southbound overlap with Route 3. After leaving the overlap, it continues east, passing over I-91, and proceeding to the Connecticut River, which it crosses into Glastonbury via the Rocky Hill-Glastonbury Ferry. In Glastonbury, it continues east to end at an intersection with Route 17.

A 1.06-mile (1.71 km) section of Route 160 in Glastonbury, running from the Connecticut River to Roaring Brook, is designated a scenic road.

The Rocky Hill-Glastonbury Ferry began service in 1655. In 1932, it was incorporated into the newly commissioned Route 160. Since then, Route 160 has had no major changes. In 1960, a request by the Town of Glastonbury to extend Route 160 east to the New London Turnpike, near Route 2, was declined by the state.

The entire route is in Hartford County.