State Highway 78 is a highway connecting Pueblo to the town of Beulah and the San Isabel National Forest.

SH 78 runs 33.2 miles (53.4 km), starting at a junction with Colorado State Highway 165 in San Isabel National Forest and ending at a junction with Colorado State Highway 45 in Pueblo. A short spur route, also marked as SH 78 runs 1.5 miles (2.4 km) from the main highway, ending at the intersection of Grand and Pennsylvania avenues in Beulah.