Route 144 is a highway in Ste. Genevieve County, Missouri. Its eastern terminus is within Hawn State Park; its western terminus is at Route 32 in Millers.

In the west, Route 144 begins at Route 32 in Millers. It heads south-southeast through rural land, crossing Jonca Creek and approaching Hawn State Park. Upon reaching Hawn Park Road, Route 144 turns eastward and parallels the northern boundary of the park. The road enters the park and bends northward slightly before terminating at Bauer Road.

The road was designated by 1972; it has not been altered since.