State Route 253, also known as the Ukiah–Boonville Road, is a highway in Mendocino County, California. It runs from California State Route 128 near Boonville to U.S. Route 101 near Ukiah, connecting the Anderson Valley to the Ukiah Valley across the mountains of the Mendocino Range.

The road begins in Boonville at an at-grade intersection with SR 128. The road heads eastward through a forested and mountainous area for approximately fifteen miles before entering the Russian River Basin, where numerous farms exist. The road ends with an interchange with U.S. Route 101 in southern Ukiah.

This route, under the name of the Ukiah-Boonville Road, has been in use as a road since at least 1897, when it was the scene of the robbery of a stage coach carrying the payrolls for a coastal lumber mill. However, it was not a state highway until 1963, when it was added to the state highway system. It was given its present number in the 1964 state highway renumbering.

Except where prefixed with a letter, postmiles were measured on the road as it was in 1964, and do not necessarily reflect current mileage. The entire route is in Mendocino County.