In the U.S. state of Arizona, U.S. Route 89 is a U.S. Highway that begins in Flagstaff and heads north to the Utah border northwest of Page.

U.S. 89 begins at Flagstaff, Arizona, the highway proceeds north passing near Grand Canyon National Park and through the Navajo Nation. Near the Utah State Line the highway splits into U.S. 89 and U.S. 89A. The Alternate is the original highway, what is now the main highway was constructed in the 1960s to serve the Glen Canyon Dam. The two highways rejoin in Kanab, Utah.

The main branch passes over the Colorado River just south of the Glen Canyon Dam and Lake Powell near Page then enters Utah. The Alternate branch crosses the Colorado River at Navajo Bridge and proceeds to the North Rim of the Grand Canyon before entering Utah.

Prior to 1992, the southern terminus of U.S. 89 was at Nogales, Arizona. U.S. 89 ran concurrently with Interstate 19 until Green Valley where it proceeded north along what is now Interstate 19 Business. The route was taken (in a northerly direction) through Tucson via 6th Avenue, Congress Street and Granada Avenue. The route was carried out of Tucson via State Route 77. Further north it was carried via the Pinal Pioneer Parkway northwest out of Oracle Junction on State Route 79. In Maricopa County, it ran concurrently with existing U.S. Route 60 along Main Street in Mesa, Apache Boulevard and Mill Avenue in Tempe, then along Van Buren Street in Phoenix to Grand Avenue, then to Wickenburg. Departing Wickenburg, it followed U.S. Route 93 and State Route 89 to Prescott. Departing Prescott, the route followed State Route 89A.

The alignment nears Interstate 17 at the Flagstaff Pulliam Airport but never ran concurrently with Interstate 17 as Interstate 17 replaced it. The interstate 17 - Interstate 40 improvements removed evidence of the original U.S. 89.

In Flagstaff, Arizona, U.S. 89 ran along Milton Road and Santa Fe Avenue.The highway crossed the Little Colorado River at Cameron on the Cameron Suspension Bridge until 1959, when the bridge was retired and replaced by a parallel span.

As of February, 2013, U.S. Rt. 89 is closed indefinitely in both directions approximately 25 miles south of Page, Arizona due to a geological event that caused the roadway to buckle and subside. Traffic is being re-routed via 45 miles of secondary and tertiary roads on the Navajo Reservation. Alternate routes through Las Vegas, NV or Hurricane, UT and Marble Canyon (U.S. 89A) are suggested.

The entire route is in Coconino County.