Pennsylvania Route 82 (PA 82) is a 31-mile (50 km) long north–south state highway located in southeast Pennsylvania, USA. The northern terminus is at PA 23 in Elverson. The southern terminus is at the Delaware state line southeast of Kennett Square, where PA 82 continues south as Delaware Route 82.

PA 82 begins as Creek Road at the Delaware state line where it meets the northern terminus of Delaware Route 82 in Kennett Township. PA 82 has many curves in Kennett Township. PA 82 enters Kennett Square, near the home of Kentucky Derby winner Barbaro, a popular horse euthanized because of injury complications in the last week of January, 2007.

PA 82 is called South Street and Union Street. In downtown Kennett Square, PA 82 meets Baltimore Pike as State Street. North of Kennett Square, PA 82 meets U.S. Route 1. North of US 1 in East Marlborough Township, PA 82 is called Unionville Road and in Willowdale it meets Pennsylvania Route 926. In Unionville, PA 82 begins to turn towards the west and is called Doe Run Road and has a concurrency with Pennsylvania Route 842. While merged with PA 842, PA 82 meets the southern terminus of Pennsylvania Route 162. In West Marlborough Township, PA 82 meets the northern terminus of Pennsylvania Route 841. In the city of Coatesville, PA 82 is called Strode Avenue and meets the eastern terminus of Pennsylvania Route 372. In downtown Coatesville, PA 82 has a concurrency with U.S. Route 30 Business. North of US 30 BUS, PA 82 meets U.S. Route 30 at an interchange.

In West Brandywine Township, PA 82 meets Pennsylvania Route 340 and PA 82 is called Manor Road. In Brandywine Manor, PA 82 meets U.S. Route 322. In West Nantmeal Township, PA 82 meets the northern terminus of Pennsylvania Route 282. North of PA 282, PA 82 meets the southern terminus of Pennsylvania Route 345. South of Elverson, PA 82 passes over Interstate 76 (Pennsylvania Turnpike) then meets Pennsylvania Route 401. In Elverson, PA 82 is called Chestnut Street and ends at Pennsylvania Route 23.

Prior to 2008, PA 82 continued north on Chestnut Street and entered Berks County. It was called Elverson Road, Twin Valley Road and Haycreek Road. In Birdsboro, PA 82 was called Furnace Street and had a small concurrency with Pennsylvania Route 724. PA 82 then terminated at a "T" intersection with U.S. Route 422.

On September 8, 1987, torrential rains flooded Hay Creek for days and destroyed several trestles that cross Hay Creek just south of Birdsboro. Over the coming months, local residents got used to the lack of traffic and fought to keep the road permanently closed, forcing PennDOT to forgo any possible bridge replacement. However, they did rebuild the bridge just south of Douglas Street. As a result, PA 82 was impossible to transverse from end to end. In late 2008, PennDOT decommissioned this section of PA 82 north of Elverson making the old section of PA 82 in Chester County SR 4082 and the section in Berks County SR 2082. The bulk of this area is now known as Berks County Park. Some GPS systems still mark this road as PA 82 and may not have the destroyed section of road blocked off on current maps. In September 2010, PennDOT decided to hand over the closed portion of the former PA 82 to local landowners.

When this section of PA 82 was decommissioned, PA 345 was extended north of its previous terminus in Birdsboro at PA 724 along PA 724 and then along the former routing of PA 82 to US 422.

The entire route is in Chester County.