State Route 616 (SR 616, OH 616) is a north–south state highway in the northeastern portion of the U.S. state of Ohio. The southern terminus of State Route 616 is at a signalized intersection with State Route 170 immediately south of U.S. Route 224 in Poland. The northern terminus of the state highway is at a signalized intersection that doubles as the eastern end of the triplex of U.S. Route 62, State Route 7 and State Route 304 in Hubbard.

Along its path, State Route 616 passes through northeastern Mahoning County and southeastern Trumbull County. No stretch of State Route 616 is included within the National Highway System, a network of highways deemed most vital for the nation's economy, mobility and defense.

State Route 616 was established in 1939. From its inception, it has maintained the same Poland-to-Hubbard alignment that it utilizes today. There have been no changes of major significance to the routing of State Route 616 since it debuted.