State Route 380 is a short east–west highway in McMinnville, Tennessee. The current length is 4.2 mi (6.8 km).

The highway begins at an intersection with SR-55, U.S. Route 70S, and SR-1 in western McMinnville. U.S. 70S/SR-1 moves east from Woodbury and turns north at this intersection. SR-55 begins at the south fork of the intersection and SR-380 begins at the east fork.

SR-380 moves southeast into downtown McMinnville as West Main St and becomes two separate one-way streets in downtown. Eastbound SR-380 retains the name West Main St (which becomes East Main St after an intersection with SR-56) and westbound SR-380 is called West Morford St (which becomes East Morford St after an intersection with SR-56). This goes for approximately 0.5 miles (0.80 km) until both streets come back together to form Sparta St just east of downtown. SR-380 (Sparta St) continues northeast before terminating at U.S. 70S/SR-1.