Route 141 is a west–east state highway in the U.S. state of Massachusetts. Its western terminus is at Route 10 in Easthampton. Its eastern terminus is at U.S. Route 20 in Springfield while concurrent with Route 21.

An odd sight greeted motorists in Easthampton in July, 2005 on Route 10 at the western terminus of Route 141: standard issue Alabama state highway signs with the numbers 10 and 141 in a map of that state, instead of the standard Massachusetts square. This odd "Alabama 10" and "Alabama 141" signage came about when a contractor mistakenly applied the sample from a federal manual.