State Route 295 or SR-295 is a 3.185-mile (5.126 km) state highway that serves the central areas of Grove Hill in central Clarke County. SR-295 intersects US-43 at both its southern and northern termini.

State Route 295 begins at its intersection with US-43 just south of Grove Hill. The route progresses in a northerly direction past the Grove Hill Memorial Hospital just prior to reaching its intersection with US-84. SR-295 continues in its northerly track through the central business district of Grove Hill prior to intersecting US-43 at its northern terminus north of the town.

The entire route is in Grove Hill, Clarke County.