State Route 154 or SR-154 is a 29.480-mile (47.443 km) state highway that serves as an east-west connection between Coffeeville and Thomasville through Clarke County. SR-154 intersects SR-69 at its western terminus and US-43 at its eastern terminus.

State Route 154 begins at its intersection with SR-69 north of Coffeeville. From this point, SR-154 follows a meandering east to northeast course through central Clarke County in route to its eastern terminus at US-43 in Thomasville.

The entire route is in Clarke County.