South Carolina Highway 88 (SC 88) is a 14.9-mile (24.0 km) state highway in northern Anderson County, South Carolina, connecting Pendleton and areas south of Powdersville. It is sometimes considered an alternate route for U.S. Highway 123.

The route travels generally in a west–east direction, beginning at an intersection with S.C. Highway 28 Business in downtown Pendleton. East of Pendleton, SC 88 travels through somewhat rural areas and has a flashing stop light intersection with U.S. Highway 178. The route continues until it terminates at an intersection with S.C. Highway 8 and S.C. Highway 81, west of the suburban areas of Powdersville.